Round Immature Spermatogenic Cells in Semen Fluids of Infertile Men with Diagnosis “Migrating Testis”. Two Casuistic Cases in Adults
Abstract: The spermatological analysis of ejaculates from two patients suffering of low male fertility and with diagnosis “migrating” testis syndrome (casuistic cases in adults), reveals cytological characteristics of different immature spermatogenic cells (“round cells”) as precursors of spermatozoa. The high quantity of undifferentiated spermatocytes/spermatides in ejaculates is important for early diagnoses of andro- logical diseases
ART and varicocele repair in men with non-obstructive azoospermia (NOA): Although the use of ART is inevitable in men with spermatogenic deficiency, varicocele repair can recover healthy sperm in the ejaculate of infertile men with NOA and clinical varicocele, and thus lower the need for ART and the associated costs . The chance of sperm
Distinction between obstructive and non-obstructive azoospermia Prior to initiating treatment for a couple, in whom the man has azoospermia, it is important to distinguish whether the lack of sperm in the ejaculate is from an obstructive or non-obstructive process. In addition, careful evaluation of the post-ejaculate urinalysis is necessary to rule out retrograde ejaculation, common
Hormone suppression with GnRH antagonist promotes spermatogenic recovery from transplanted spermatogonial stem cells in irradiated cynomolgus monkeys.
Hormone suppression given before or after cytotoxic treatment stimulates the recovery of spermatogenesis from endogenous and transplanted spermatogonial stem cells (SSC) and restores fertility in rodents. To test whether the combination of hormone suppression and transplantation could enhance the recovery of spermatogenesis in primates, we irradiated (7 Gy) the testes of 12 adult cynomolgus monkeys and
Human induced pluripotent stem cells and male infertility: an overview of current progress and perspectives.
ABSTRACT: Recently, significant progress has been made in ART for the treatment of male infertility. However, current ART has failed to help infertile patients with non-obstructive azoospermia, unless donor sperm is used. In fact, most couples wish to have their own genetically related child. Human induced pluripotent stem cells (hiPSCs) can be generated from patients’
Somatic stem cells also called adult stem cells, exist naturally in the body. They are important for growth, healing, and replacing cells that are lost through daily wear and tear. Stem cells from the blood and bone marrow are routinely used as a treatment for blood-related diseases. However, under natural circumstances somatic stem cells
Stem Cell Therapy for Infertility! What’s new? What are Stem Cells? Stem cells, by definition, have the potentials of both self-renewal and differentiation into specialized cell types. Currently there are three major stem cell sources for generating male differentiated germ cells: the embryonic stem cells, the induced pluripotent stem cells, and spermatogonial stem cells. Embryonic
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Researchers have found a solution for a common form of male infertility. Nonobstructive azoospermia is a condition in which sperm do not grow to maturity. Japanese researchers have now reported a way to extract immature sperm from the testicle and use it for in vitro fertilization. They are using it successfully at a clinic in
ABSTRACT Introduction: Most male patients with non-obstructive azoospermia (NOA) have no therapeutic options outside of assisted reproductive techniques to conceive a biological child. If mature sperm cannot be obtained from the testes, these patients must rely on options of donor sperm or adoption. Several techniques are in the experimental stage to provide this patient population
Background: Spermatogonial stem cells (SSCs) are unique in mammals because they can transmit genetic information from generation to generation and it is of significant importance. In testes, Sertoli cells, peritubular myoid cells, Leydig cells and other interstitial cells contribute to the spermatogonial stem cell “niche”. So, creation of niche in an in vitro condition that
Embryo implantation is complicated, as you can imagine! But here’s a breakdown of some of the key elements that can help you maximize your chances: 1. Oocyte (egg) quality Implantation is more likely to happen when a healthy embryo is present, and the best predictor for a healthy embryo is a healthy egg. Egg quality is based