Future of Spermatogonial Stem Cell Culture: Application of Nanofiber Scaffolds

Background: Spermatogonial stem cells (SSCs) are unique in mammals because they can transmit genetic information from generation to generation and it is of significant importance. In testes, Sertoli cells, peritubular myoid cells, Leydig cells and other interstitial cells contribute to the spermatogonial stem cell “niche”. So, creation of niche in an in vitro condition that

How do I improve my chances for embryo implantation?

Embryo implantation is complicated, as you can imagine! But here’s a breakdown of some of the key elements that can help you maximize your chances:1. Oocyte (egg) qualityImplantation is more likely to happen when a healthy embryo is present, and the best predictor for a healthy embryo is a healthy egg. Egg quality is based on a

The Future of Azoospermic Patients: In vitro

Male infertility becomes a worldwide problem and contributed to 50% of infertility cases [1]. The main cause of male infertility is spermatogenesis failure such as oligozoospermia and azoospermia. Azoospermia is defined as absence of spermatozoa from semen and it is present in 15% of infertile [2]. It is a major concern due to unability to

6 ways to increase sperm count

1) Coffee, drinks and cigarettes Caffeine, alcohol and cigarettes are wildly popular and definitely part of our modern urban culture. Unfortunately they also harm fertility and decrease conception rates. If you enjoy several coffees per day and a few drinks in the evening after (or during) work it is a good idea to cut back

Vitamin B12‑induced spermatogenesis recovery in cimetidine

Flávia L Beltrame1 , Estela Sasso‑Cerri2 The H2‑receptor antagonist cimetidine is an antiulcer drug also used for the treatment of cancer due to its antiangiogenic effect. However, this drug has caused structural changes in the seminiferous tubules. Vitamin B12 has been used as a therapeutic agent for the treatment of male infertility. The supplementation of

Testicular histology may predict the successful sperm retrieval in patients with non-obstructive azoospermia undergoing conventional TESE: a diagnostic accuracy study

Purpose The present study sought to determine the diagnostic accuracy of FSH level, testicular volume, and testicular histology in predicting the successful sperm retrieval (SSR) in a large cohort of patients with non-obstructive azoospermia undergoing conventional testicular sperm extraction (TESE). Methods We retrospectively evaluated 356 patients with non-obstructive azoospermia between June 2004 and July 2009.

Turning Stem Cells Into Sperm (Still under Research)

By: Ian Murnaghan BSc (hons), MSc – Updated: 12 Mar 2017 Turning Stem Cells Into Sperm There are many different reasons to find ways to create sperm from stem cells – one of these is to help infertile couples have children. It’s an enormous field of work and thus far, it’s looking as though stem

Experimental methods to preserve male fertility and treat male factor infertility

Experimental methods to preserve male fertility and treat male factor infertility This review describes several technologies that are currently in the research pipeline and may expand fertility options for men in the future. Each technology described in this review has produced functional sperm and progeny in at least one animal model, but none except SSC

Processing and selection of surgically-retrieved sperm for ICSI: a review

Abstract Although the technique of intracytoplasmic sperm injection (ICSI) has been a revolution in the alleviation of male infertility, the use of testicular sperm for ICSI was a formerly unseen breakthrough in the treatment of the azoospermic man with primary testicular failure. At the clinical level, different procedures of testicular sperm retrieval (conventional TESE, micro-TESE,

The Genetics of Infertility: Current Status of the Field

The Genetics of Infertility: Current Status of the Field     Michelle Zorrilla and Alexander N Yatsenko* Departments of Obstetrics, Gynecology and Reproductive Sciences, Pathology, School of Medicine, University of Pittsburgh Abstract: Infertility is a relatively common health condition, affecting nearly 7% of all couples. Clinically, it is a highly heterogeneous pathology with a complex

The Regenerative Effect of Bone Marrow-Derived Stem Cells in Spermatogenesis of Infertile Hamster.

Abstract BACKGROUND: Infertility is a serious social problem in advanced nations, with male factor in half of all cases of infertility. This study was conducted to determine the regenerative effect of bone marrow-derived stem cells in spermatogenesis of infertile hamster. METHODS: Twelve adult male hamsters were equally divided into azoospermic and control groups. Busulfan was