Sperm fine-needle aspiration Abstract We sought to evaluate the ability of fine-needle aspiration (FNA) mapping to find sperm and to guide sperm retrieval after failed microdissection testicular sperm extraction (micro-TESE) in nonobstructive azoospermic men. In this study of consecutive male infertility cases, interventions included testicular FNA mapping and subsequent sperm...
Round Immature Spermatogenic Cells in Semen Fluids of Infertile Men with Diagnosis “Migrating Testis”. Two Casuistic Cases in Adults
Round Immature Spermatogenic Cells in Semen Abstract: The spermatological analysis of ejaculates from two patients suffering of low male fertility and with diagnosis “migrating” testis syndrome (casuistic cases in adults), reveals cytological characteristics of different immature spermatogenic cells (“round cells”) as precursors of spermatozoa. The high quantity of undifferentiated spermatocytes/spermatides...
Role of varicocele treatment in assisted
ART and varicocele repair in men with non-obstructive azoospermia (NOA): Although the use of ART is inevitable in men with spermatogenic deficiency, varicocele repair can recover healthy sperm in the ejaculate of infertile men with NOA and clinical varicocele, and thus lower the need for ART and the associated costs...
Obstructive vs. Non-Obstructive Azoospermia
The distinction between obstructive and non-obstructive azoospermia Prior to initiating treatment for a couple, in whom the man has azoospermia, it is important to distinguish whether the lack of sperm in the ejaculate is from an obstructive or non-obstructive process. In addition, careful evaluation of the post-ejaculate urinalysis is necessary...
Hormone suppression with GnRH antagonist promotes spermatogenic recovery from transplanted spermatogonial stem cells in irradiated cynomolgus monkeys.
Hormone suppression given before or after cytotoxic treatment stimulates the recovery of spermatogenesis from endogenous and transplanted spermatogonial stem cells (SSC) and restores fertility in rodents. To test whether the combination of hormone suppression and transplantation could enhance the recovery of spermatogenesis in primates, we irradiated (7 Gy) the testes of...
Human induced pluripotent stem cells and male infertility: an overview of current progress and perspectives.
ABSTRACT: Recently, significant progress has been made in ART for the treatment of male infertility. However, current ART has failed to help infertile patients with non-obstructive azoospermia, unless donor sperm is used. In fact, most couples wish to have their own genetically related child. Human induced pluripotent stem cells (hiPSCs)...
Adult Stem cell therapy for azoospermia
Somatic stem cells also called adult stem cells, exist naturally in the body. They are important for growth, healing, and replacing cells that are lost through daily wear and tear. Stem cells from the blood and bone marrow are routinely used as a treatment for blood-related diseases. However, under...
Stem Cell Therapy for Azoospermia! What’s new??
Stem Cell Therapy for Infertility! What’s new? What are Stem Cells? Stem cells, by definition, have the potentials of both self-renewal and differentiation into specialized cell types. Currently, there are three major stem cell sources for generating male differentiated germ cells: the embryonic stem cells, the induced pluripotent stem cells,...
Japanese researchers solve common form of male infertility
Researchers have found a solution for a common form of male infertility. Nonobstructive azoospermia is a condition in which sperm do not grow to maturity. Japanese researchers have now reported a way to extract immature sperm from the testicle and use it for in vitro fertilization. They are using it...
Biological therapy for non-obstructive azoospermia
ABSTRACT Introduction: Most male patients with non-obstructive azoospermia (NOA) have no therapeutic options outside of assisted reproductive techniques to conceive a biological child. If mature sperm cannot be obtained from the testes, these patients must rely on options of donor sperm or adoption. Several techniques are in the experimental stage...
Future of Spermatogonial Stem Cell Culture: Application of Nanofiber Scaffolds
Background: Spermatogonial stem cells (SSCs) are unique in mammals because they can transmit genetic information from generation to generation and it is of significant importance. In testes, Sertoli cells, peritubular myoid cells, Leydig cells and other interstitial cells contribute to the spermatogonial stem cell “niche”. So, creation of niche in...
How do I improve my chances for embryo implantation?
Embryo implantation is complicated, as you can imagine! But here’s a breakdown of some of the key elements that can help you maximize your chances:1. Oocyte (egg) qualityImplantation is more likely to happen when a healthy embryo is present, and the best predictor for a healthy embryo is a healthy...