Experimental methods to preserve male fertility and treat male factor infertility

Experimental methods to preserve male fertility and treat male factor infertility

Experimental methods to preserve male fertility and treat male factor infertility

This review describes several technologies that are currently in the research pipeline and may expand fertility options for men in the future. Each technology described in this review has produced functional sperm and progeny in at least one animal model, but none except SSC transplantation has been deployed in the human fertility clinic as of yet. In all cases, fundamental translational and preclinical studies of safety and feasibility are still needed.

Abstract:

Infertility is a prevalent condition that has insidious impacts on the infertile individuals, their families, and society, which extend far beyond the inability to have a biological child. Lifestyle changes, fertility treatments, and assisted reproductive technology (ART) are available to help many infertile couples achieve their reproductive goals. All of these technologies require that the infertile individual is able to produce at least a small number of functional gametes (eggs or sperm). It is not possible for a person who does not produce gametes to have a biological child. This review focuses on the infertile man and describes several stem cell-based methods and gene therapy approaches that are in the research pipeline and may lead to new fertility treatment options for men with azoospermia.

Key Words

Fertility
infertility
transplantation
grafting
culture
de novo testicular morphogenesis
gene therapy

Read Full Article: http://ac.els-cdn.com/S0015028215021986/1-s2.0-S0015028215021986-main.pdf?_tid=85eedc86-4e8c-11e7-a416-00000aab0f27&acdnat=1497175290_2d32bc0e4d3e47179e12063c8772d7ae

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