Stage I treatment increase the Spermatogonium cells (spermatogonial stem cells) number.
Recently, studies have reported (click here to download) that spermatogonial stem cells could be isolated from testicular tissue of non-obstructive azoospermic patients. Spermatogonial stem cells have both self-renewal and differentiation abilities, and are tightly controlled in the stem cell niche.
The presences of spermatogonial stem cells give us the hope to restore the non-obstructive azoospermic patients’ fertility.
The reasons of block in spermatogonial differentiation are not know yet, but studies (click here to download) showing that this block was due to damage to the somatic environment. They also found that in many such cases, suppression of testosterone for a short period of time could restore spermatogonial stem cells divisions.
Stage II treatment increase the Spermatogonial Stem cells differentiation (early stages of spermatogenesis).
Stage two has similar effect like stage one that increase the division of the stem cells, Stage two has also additional components that push the stem cells to differentiate to the next stages.
Stage III treatment is the final stage, it is increase the sperm count, sperm motility and sperm quality.
Patients that start with Stage I (increase spermatogonial stem cells number) must take Stage II (increase spermatogonial stem cells differentiation) and then they need to take Stage III that increase the sperm production.
Patients with normal spermatogenesis but they suffering from low sperm count or low sperm motility or low sperm quality they can take Stage III treatment for 3 months or more.