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Microdissection TESE is superior to conventional TESE in patients with nonobstructive azoospermia caused by Y chromosome microdeletions.

Nonobstructive azoospermia is caused in up to 10% by microdeletions of the Y chromosome in the azoospermia factor (AZF) region, which is divided into three nonoverlapping areas (AZFa, AZFb and AZFc). In 25 male patients with AZF microdeletions, the results of two different techniques for surgical sperm retrieval (SR), conventional multilocular TESE and microdissection TESE,

Evidence of spermatogonial stem cell presence in men with sertoli cell-only syndrome

Phil Bach*, Anna Mielnik, Alexander Bolyakov, Bobby Najari, Peter Schlegel, Darius Paduch, New York, NY INTRODUCTION AND OBJECTIVES: Sertoli cell-only syndrome (SCOS) is one of the most severe forms of male factor infertility and is classically thought to be devoid of germ cells. However, evidence from microsurgical testicular sperm extractions (TESE) on patients with SCOS

why do undescended testes cause infertility?

Cryptorchidism or undescended testis is one of the most common anomalies encountered in paediatric urology and is estimated to affect 1 to 4 per cent of full term and upto 30 per cent of preterm male neonates. The associated problems of sub-fertility or infertility and malignant transformation have been recognized for long. Over the last

Severe Testicular Atrophy does not Affect the Success of Microdissection Testicular Sperm Extraction

Men with azoospermia and severe testicular atrophy may be counseled to avoid sperm retrieval due to perceived limited success. We evaluated the outcomes of micro-dissection testicular sperm extraction in men with severe testicular atrophy (volume 2 ml or less). Materials and Methods: We reviewed the records of 1,127 men with non-obstructive azoospermia who underwent micro-dissection

Successful fertilization and embryo development after spermatid injection: A hope for nonobstructive azoospermic patients

Spermatids are the earliest male germ cells with haploid set of chromosomes. Spermatid injection was introduced in human assisted reproduction for the treatment of men with non-obstructive azoospermia. Spermatozoa can be recovered in half of patients with nonobstructive azoospermia. The use of spermatids for intracytoplasmic injection (ICSI) has been proposed for cases in which no

Evaluation of 'round cells' in semen analysis: a comparative study

Abstract The aims of this review are to evaluate the morphological differences between ‘round cells‘ of spermatogenic and non-spermatogenic origin in semen. The latter group includes inflammatory cells like neutrophils, lymphocytes, and macrophages, and epithelial cells. A comparison was made between non-spermatogenic cells in semen samples and inflammatory cells in blood smears, using various staining

Couples with non-obstructive azoospermia are interested in future treatments with artificial gametes.

Abstract STUDY QUESTION: Would couples diagnosed with non–obstructive azoospermia (NOA) consider two future treatments with artificial gametes (AGs) as alternatives for testicular sperm extraction followed by ICSI (TESE-ICSI)? SUMMARY ANSWER: Most couples with NOA (89%) would opt for treatment with AGs before attempting TESE-ICSI and/or after failed TESE-ICSI. WHAT IS KNOWN ALREADY: Couples with NOA

Microfluidics: The future of microdissection TESE?

ABSTRACT Non-obstructive azoospermia (NOA) is a severe form of infertility accounting for 10% of infertile men. Microdissection testicular sperm extraction (microTESE) includes a set of clinical protocols from which viable sperm are collected from patients (suffering from NOA), for intracytoplasmic sperm injection (ICSI). Clinical protocols associated with the processing of a microTESE sample are inefficient

Men fertility Management

What is male infertility? Reproduction (or making a baby) is a simple and natural experience for most couples. However, for some couples it is very difficult to conceive. A man’s fertility generally relies on the quantity and quality of his sperm. If the number of sperm a man ejaculates is low or if the sperm

Maturation Arrest – Case Report - Fully Detailed Success Story

Maturation Arrest – Case Report – Fully Detailed Success Story This Patient contact us on 7-September-2013; please find all the correspondence with him (we cannot publish his name and details according to his request) from the beginning to the end   Patient (7-Sep-2013): “Diagnosed as azoospermian person with a maturation arrest. Sex hormones seems more often

Stem cell transplantation for treatment of azoospermia?

Azoospermia is defined as the complete lack of sperm in the ejaculate. In humans, Azoospermia affects about 1% of the male population and may be seen in up to 20% of male infertility situations. In testicular Azoospermia the testes are abnormal, atrophic, or absent, and sperm production severely disturbed to absent. FSH levels tend to