We are pleased to share new clinical data presented at the ESHRE 2026 Annual Meeting evaluating the effect of Prolistem in men with non-obstructive azoospermia (NOA) who had previously undergone two unsuccessful microTESE procedures.
In this retrospective clinical study conducted at Momart IVF Center (Turkey):
29 men with NOA and a history of repeated failed microTESE received Prolistem treatment.
After treatment, 3 of 29 patients (10.3%) had sperm detected in their ejaculate.
Among the remaining patients, 13 underwent a repeat (third) microTESE, and 3 patients (23.1%) achieved successful sperm retrieval.
Overall, sperm became available for assisted reproduction in 6 patients, with three ongoing pregnancies reported during follow-up and no treatment-related adverse events observed.
These findings are encouraging because they suggest that a subset of men who had previously failed two microTESE procedures may still achieve sperm retrieval following Prolistem treatment. While the study is retrospective and relatively small, its results are consistent with previous clinical experience evaluating Prolistem in carefully selected men with non-obstructive azoospermia.
We thank the investigators at Momart IVF Center for their valuable contribution to advancing research in male infertility and look forward to additional prospective studies that will further define which patients are most likely to benefit from this approach.
