Prolistem® is a patented, all-natural treatment specifically developed for men with non-obstructive azoospermia (NOA)—a condition in which the testicles fail to produce sperm. Unlike common fertility supplements aimed at improving sperm quality in men with low counts, Prolistem® addresses the root cause of sperm production failure.
This groundbreaking six-month protocol is certified for free sale by the FDA and built on over 15 years of research in male infertility. It is the first clinically supported supplement designed to reignite spermatogenesis in men once told that fatherhood was out of reach.
In clinical data, Prolistem® achieved a 48% overall success rate:
23% of men had sperm appear naturally in their semen, making IVF possible (note: spontaneous pregnancies remain rare in NOA).
25% had sperm successfully retrieved through micro-TESE after completing the full protocol.
Prolistem® is a two-phase treatment protocol, scientifically engineered to restore sperm production by targeting hormonal, cellular, and metabolic pathways that govern spermatogenesis.
Years of research from institutions such as MD Anderson Cancer Center, Houston, Texas, have shown that high intratesticular testosterone levels can suppress germ cell development in men with NOA. In contrast to the traditional view that testosterone is always beneficial, these studies revealed that temporary suppression may actually reawaken dormant spermatogonial stem cells.
Prolistem® Phase One uses a proprietary compound—glycyrrhizic acid, which converts in the body to glycyrrhetinic acid. This compound inhibits 17β-HSD, an enzyme that drives testosterone synthesis, allowing a temporary hormonal reset.
This reset triggers activation of critical cell-signaling pathways like MAPK, PI3K/Akt, and Notch, which are essential for restarting early-stage sperm development. It’s like pressing a biological reset button—giving the testicles a chance to begin again.
Once early germ cells are reactivated, Prolistem® Plus (Phase Two) works to rebuild the full sperm production process by:
Restoring testosterone levels naturally
Delivering Retinoic Acid (Vitamin A) to guide undifferentiated germ cells through meiosis
Providing antioxidants and polyphenols like resveratrol, ellagic acid, punicalagins, and quercetin to reduce DNA fragmentation and protect developing sperm
Enhancing Leydig and Sertoli cell function with targeted nutrients including Vitamins D, E, B12, zinc, Icariin, L-dopa, and more
Improving hormonal balance and cellular energy for optimal spermatogenesis
Microscopic studies show a remarkable transformation:
Before treatment (Picture A), NOA patients typically show “empty” tubules with only Sertoli cells. After Prolistem® therapy, signs of spermatogenesis appear, indicating germ cells are back in action (Picture B).
Most fertility products on the market are designed to support sperm health in men with low sperm counts (oligospermia). They do not address the absence of sperm, nor the underlying testicular dysfunction in NOA.
Prolistem® is different. It is the only non-hormonal, natural treatment specifically created to support sperm recovery in NOA. Its effectiveness lies in its foundation:
Built on published research in human spermatogenesis and stem-cell biology
Inspired by evidence from clinical studies showing that testosterone suppression can restore sperm production in NOA
Scientifically formulated to work with the body’s biological rhythms, not against them
Proven in real patients with successful IVF and surgical sperm retrieval outcomes
This is not just a supplement. It’s a science-driven protocol backed by data and designed for one of the most difficult fertility challenges in men.
If you’ve been diagnosed with NOA, or if you’ve had failed biopsies or micro-TESE attempts, Prolistem® offers renewed hope. Our approach is rooted in science, built on trust, and committed to helping men become fathers.
Contact our team today to learn more, or explore the published clinical study.
With every Prolistem® kit purchased in the USA, you will receive a free SpermSure™ Home Semen Collection Kit for 12 weeks.
To maximize your chances of success, frequent semen analysis is essential. The SpermSure™ Kit allows you to collect semen samples privately and conveniently from home.
The SpermSure Kit is free of charge
Lab analysis cost: $150 (covers all 12 samples)
Once you’ve completed the 12 collections, simply ship the samples to our certified U.S. lab. We will analyze them and email you a detailed report.
What do the results mean?
If your body produces even a small amount of sperm, we will detect it. This helps identify the optimal timing for performing a clinical semen analysis or scheduling a microTESE.
According to U.S. and Canadian guidelines, up to 10% of men with azoospermia may produce sperm intermittently, but timing is critical.
With SpermSure™, we cover your entire spermatogenic cycle, giving you the best chance to detect sperm when it appears.SPermSure
The Prolistem Kit includes:
6 bottles of Prolistem: 3 bottles of Phase One (Orange) and 3 bottles of Phase Two (Purple)
Free SpermSure Kit for US Orders only (Semen Collection Kit for 12 weeks of use)
Customs, Taxes, and Buyer Responsibility
Thank you for choosing to shop with us! Please be aware that we are located in the USA, and international shipping may be subject to customs checks, import duties, taxes, and other fees imposed by the destination country.
Any applicable customs fees, taxes, or import duties are the buyer’s sole responsibility and are not included in our product prices or shipping charges. Before placing your order, we recommend checking your country’s customs office for more details regarding potential fees and taxes.
We appreciate your understanding and support!
$590.00
Prolistem, a patented formula, has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
PROLISTEM® is a Patented Formula
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