How successful is TESE-ICSI in couples with non-obstructive azoospermia?

STUDY QUESTION: What are the chances of a couple with infertility due to non-obstructive azoospermia (NOA) having their genetically own child by testicular sperm extraction combined with ICSI (TESE-ICSI)? SUMMARY ANSWER: Candidate TESE-ICSI patients with NOA should be counselled that, when followed-up longitudinally, only a minority (13.4%) of men embarking for TESE eventually become a

Stem Cell and Azoospermia

Spermatogenesis is the process by which undifferentiated germ cells in the testis divide and mature. Continuous function of this process, which produces millions of spermatozoa daily, is required for sustained male fertility. Spermatogonial stem cells (SSCs), precursors of the spermatogonial lineage, have both self-renewal and differentiation abilities, and are tightly controlled in the stem cell